TUESDAY, Aug. 31, 2021 (HealthDay Information) — A excessive quantity of coronavirus in the lungs is a significant contributor to loss of life in COVID-19 sufferers, new analysis reveals.

The findings problem earlier theories that simultaneous infections resembling pneumonia or an overreaction of the physique’s immune system are vital components in COVID-19 deaths, the researchers famous.

To come back to that conclusion, the investigators analyzed bacterial and fungal samples from the lungs of 589 hospitalized COVID-19 sufferers who have been severely unwell and required mechanical air flow.

On common, sufferers who died had 10 instances the quantity of virus of their decrease airways than those that survived their sickness.

“Our findings counsel that the physique’s failure to deal with the massive numbers of virus infecting the lungs is basically chargeable for COVID-19 deaths within the pandemic,” stated lead research writer Dr. Imran Sulaiman, an adjunct professor in NYU Langone Well being’s division of medication.

There was no proof of secondary bacterial infection as the reason for the deaths, however this can be as a result of the sufferers obtained giant quantities of antibiotics, stated the authors of the research printed on-line Aug. 31 within the journal Nature Microbiology.

Tips from the U.S. Facilities for Illness Management and Prevention don’t encourage giving antivirals resembling remdesivir to severely unwell COVID-19 sufferers on mechanical air flow, however these findings counsel these drugs may very well profit these sufferers, Sulaiman stated in an NYU Langone information launch.

In line with research senior writer Dr. Leopoldo Segal, an affiliate professor in NYU Langone’s division of medication, “These outcomes counsel that an issue with the adaptive immune system is stopping it from successfully combating the coronavirus. If we are able to determine the supply of this problem, we could possibly discover an efficient remedy that works by bolstering the physique’s personal defenses.”

Segal famous that the research solely included sufferers who survived their first two weeks of hospitalization, so it is doable that bacterial infections or autoimmune reactions could play a larger position in COVID-19 deaths that happen earlier.

The analysis group’s subsequent step is to analyze how the microbe group and immune response within the lungs of COVID-19 sufferers change over time, Segal stated.

The loss of life price for U.S. COVID-19 sufferers who need to be placed on mechanical respirators is about 70%.


Extra data

The U.S. Facilities for Illness Management and Prevention has extra on treatment of COVID-19.


SOURCE: NYU Langone Well being, information launch, Aug. 31, 2021